Enhancing immune response to prevent progression of smoldering myeloma
Improving immune modulation for smoldering myeloma
This study is looking at how to help the immune system better recognize and manage smoldering myeloma, which can lead to multiple myeloma, by understanding the immune cells in patients and how they change with treatment, so we can find new ways to keep the condition from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11047310 on NIH RePORTER |
What this research studies
This research investigates how to improve the immune system's ability to recognize and control smoldering myeloma, a precursor to multiple myeloma. It focuses on understanding the characteristics of immune cells in patients with smoldering myeloma and how these cells change during treatment. By evaluating the spatial architecture and states of immune cells, the research aims to identify ways to enhance immune modulation, potentially preventing the progression to clinical myeloma. Patients may receive therapies that target these immune responses to improve their outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with smoldering myeloma who are at risk of progression to multiple myeloma.
Not a fit: Patients with active multiple myeloma or those without a diagnosis of smoldering myeloma are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing the progression of smoldering myeloma to multiple myeloma, improving patient outcomes.
How similar studies have performed: Previous studies have shown promise in using immune modulation to manage precursor states of myeloma, indicating potential for success in this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Dhodapkar, Madhav V — Emory University
- Study coordinator: Dhodapkar, Madhav V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.