Enhancing HIV vaccine responses by targeting natural killer cells
Targeting natural killer cells to enhance HIV vaccine responses
This study is looking at how certain immune cells called natural killer (NK) cells influence the body's response to HIV vaccines, with the goal of finding ways to make these vaccines work better for people by boosting the production of protective antibodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10656405 on NIH RePORTER |
What this research studies
This research investigates how natural killer (NK) cells affect the immune response to HIV vaccines. It aims to understand the mechanisms by which NK cells suppress the production of protective antibodies, which are crucial for preventing HIV infection. By targeting these NK cells, the study seeks to improve the effectiveness of HIV vaccines, potentially leading to better immune responses in vaccinated individuals. The research involves both laboratory experiments and translational approaches to overcome immune regulatory barriers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of HIV infection who are interested in participating in vaccine trials.
Not a fit: Patients who are already HIV positive or those who have contraindications to vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective HIV vaccines that generate stronger and longer-lasting immune responses.
How similar studies have performed: Previous research has shown promise in enhancing vaccine responses by targeting immune cells, suggesting that this approach could be effective.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Waggoner, Stephen N. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Waggoner, Stephen N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.