Enhancing CAR-T cell therapy for HIV treatment through autophagy induction
Induction of autophagy to enhance CAR-T cells in HIV cure approaches
This study is looking at how a process called autophagy can help improve CAR-T cell therapy for people living with HIV, making these special immune cells work better and last longer to fight the virus.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11084432 on NIH RePORTER |
What this research studies
This research investigates how inducing autophagy can improve the effectiveness of CAR-T cells in treating HIV. By enhancing the function and longevity of these engineered immune cells, the study aims to overcome challenges such as immune exhaustion caused by chronic HIV infection. The researchers will use a humanized mouse model to explore the potential of autophagy in boosting CAR-T cell activity and facilitating the safe reversal of HIV latency. This approach could lead to more effective therapies for achieving a functional cure for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with chronic HIV infection who have not responded adequately to standard antiretroviral therapies.
Not a fit: Patients who are not infected with HIV or those who have acute HIV infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for HIV, potentially allowing for a functional cure.
How similar studies have performed: Previous research has shown promise in using autophagy induction to enhance immune responses, suggesting that this approach may be effective in HIV treatment as well.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zhen, Anjie — University of California Los Angeles
- Study coordinator: Zhen, Anjie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.