Enhancing CAR T cell therapy for brain tumors
Improving CAR T cell therapy for brain tumors using immune competent models
['FUNDING_OTHER'] · CHILDREN'S RESEARCH INSTITUTE · NIH-11001478
This study is looking at ways to make CAR T cell therapy better for people with high grade gliomas, a tough type of brain tumor, by tweaking the T cells to help them fight the tumor more effectively.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (WASHINGTON, UNITED STATES) |
| Trial ID | NIH-11001478 on ClinicalTrials.gov |
What this research studies
This research focuses on improving CAR T cell therapy specifically for high grade gliomas, a type of brain tumor with poor treatment outcomes. The approach involves engineering T cells to better target and attack tumor cells by optimizing their design and genetic modifications. The effectiveness of these modified T cells will be tested in immune competent mouse models that closely resemble human brain tumor conditions. By addressing challenges such as tumor microenvironment and T cell exhaustion, the research aims to enhance the immune response against these tumors.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with high grade gliomas who may benefit from advanced CAR T cell therapies.
Not a fit: Patients with other types of brain tumors or those who are not eligible for CAR T cell therapy may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with high grade gliomas, potentially improving survival rates and quality of life.
How similar studies have performed: While CAR T cell therapy has shown promise in other cancers, its application in high grade gliomas is still being explored, making this research both innovative and necessary.
Where this research is happening
WASHINGTON, UNITED STATES
- CHILDREN'S RESEARCH INSTITUTE — WASHINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAYDAR, DALIA — CHILDREN'S RESEARCH INSTITUTE
- Study coordinator: HAYDAR, DALIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.