Enhancing CAR T cell effectiveness for treating acute myeloid leukemia
Improving the activity of CAR T cells for acute myeloid leukemia
['FUNDING_CAREER'] · WASHINGTON UNIVERSITY · NIH-10876996
This study is looking at how certain immune cells called myeloid cells influence the effectiveness of CAR T cell therapy for people with acute myeloid leukemia (AML), and the researchers hope to find ways to make this treatment work better for patients.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10876996 on ClinicalTrials.gov |
What this research studies
This research investigates how myeloid cells affect the performance of CAR T cells in treating acute myeloid leukemia (AML). The team aims to understand the interactions between CAR T cells and myeloid cells, determining how these cells can either support or hinder the effectiveness of the therapy. By using advanced techniques like viral gene transfer and CRISPR/Cas9, they will modify myeloid cells to see how these changes impact CAR T cell behavior. The goal is to improve CAR T cell therapy outcomes for patients with AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia who are seeking innovative treatment options.
Not a fit: Patients with other types of leukemia or those who do not have acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective CAR T cell therapies for patients with acute myeloid leukemia.
How similar studies have performed: While CAR T cell therapies have shown success in other blood cancers, this specific approach for AML is novel and has not been extensively tested.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, MIRIAM Y — WASHINGTON UNIVERSITY
- Study coordinator: KIM, MIRIAM Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.