Enhancing cancer treatment by targeting immune cell metabolism
Official title: Metabolic Reprogramming of Myeloid Cells to Enhance Cancer Immunotherapy
Funded at Roswell Park Cancer Institute Corp · NIH-10984187 · Data updated 2026-11-12
This study is looking at how to make cancer treatments work better by focusing on certain immune cells that can hold back the body's fight against tumors, and it aims to find new ways to help patients by testing these ideas in mice.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Roswell Park Cancer Institute Corp NIH-funded |
| Lab location | 1 site (Buffalo, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $35,292 |
| NIH project number | 1F99CA294065-01 |
| Project ID | NIH-10984187 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with acute myeloid leukemia or those with cancers that exhibit a strong immune suppressive response.
✕Less likely to help
Patients with cancers that do not involve myeloid cell suppression or those who are not eligible for immunotherapy may not benefit from this research.
What this research studies
This research investigates how to improve cancer immunotherapy by focusing on myeloid cells, which can suppress the immune response against tumors. The approach involves using specific inhibitors to target the metabolism of these immune cells, potentially enhancing the effectiveness of existing cancer treatments. By studying this in mouse models, the researchers aim to identify ways to reduce tumor growth and improve patient outcomes. The ultimate goal is to develop strategies that can be translated into clinical settings for better cancer therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective cancer treatments that improve survival rates for patients with aggressive cancers like acute myeloid leukemia.
How similar studies have gone: Other research has shown promising results in targeting immune cell metabolism to enhance cancer therapies, suggesting that this approach may be effective.
Where this research is happening
-
Roswell Park Cancer Institute Corp
Buffalo, United States Active
Researchers
- Principal investigator: Morreale, Brian George — Roswell Park Cancer Institute Corp
- Study coordinator: Morreale, Brian George
Related research
Other NIH-funded projects on the same topics.
-
Boosting immune response to fight cancer
This study is exploring a new way to help your immune system better fight cancer by tweaking certain cells in your body, and it aims to improve treatment for people with advanced cancer.
-
A center focused on immunotherapy for pediatric cancers.
This study is exploring new ways to use the body's immune system to fight childhood cancers, aiming to create better treatments for kids whose cancers haven't responded well to standard therapies.
-
Algorithms to find HLA-E neoantigens for cancer immunotherapy
Aims to develop computer methods to discover tumor-specific targets presented by HLA-E to guide new T cell therapies for cancer.
-
Immunotherapy for glioblastoma: advancing treatment and understanding
A patient-friendly summary of a grant exploring new immune-based treatments for glioblastoma to improve options for people affected by this brain cancer.
-
How CRISPR-based gene activation could shape immunotherapy responses in clear cell cancers
A research project at Stanford is using CRISPR-based gene activation to understand why some clear cell ovarian and kidney cancers respond to immunotherapy while others do not.
-
Hybrid biomaterial system to boost immunotherapy for rheumatoid arthritis
A new, patient-facing immunotherapy approach uses specialized particles to retrain the immune system to calm RA in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.