Enhancing bone healing by using immune responses
Official title: ALTERING THE IMMUNE LANDSCAPE TO AUGMENT BONE REGENERATION
Funded at Texas Engineering Experiment Station · NIH-10727797 · Data updated 2026-11-12
This study is exploring how boosting the immune system with a flu vaccine can help heal bone injuries better, and it's aimed at finding new ways to improve recovery for people with broken bones.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas Engineering Experiment Station NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $369,050 |
| NIH project number | 1R21AR083057-01 |
| Project ID | NIH-10727797 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be adults who have experienced bone injuries or conditions requiring enhanced bone regeneration.
✕Less likely to help
Patients with non-bone related injuries or conditions that do not involve bone regeneration may not benefit from this research.
What this research studies
This research investigates how the immune system can be harnessed to improve bone regeneration after injury. By immunizing mice with an influenza vaccine, the study aims to deliver specific antigens to the site of bone defects using specialized scaffolds. The effectiveness of this approach will be evaluated through advanced imaging techniques and histological analysis to assess bone formation and healing over time. The research seeks to understand the role of adaptive immunity in the healing process, potentially leading to new treatments for bone injuries.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly enhance bone healing and regeneration in patients with bone injuries.
How similar studies have gone: Previous research has shown promise in using immune modulation for tissue regeneration, suggesting that this approach may yield beneficial results.
Where this research is happening
-
Texas Engineering Experiment Station
College Station, United States Active
Researchers
- Principal investigator: Alge, Daniel — Texas Engineering Experiment Station
- Study coordinator: Alge, Daniel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.