Enhanced coordinated care for people after a first episode of psychosis
Randomized controlled trial of enhanced coordinated specialty care (CSC 2.0)
This project compares an enhanced coordinated care program (CSC 2.0) to usual clinic care to help people after a first episode of psychosis stay in treatment and improve recovery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mclean Hospital NIH-funded |
| Lab location | 1 site (Belmont, United States) |
| Project ID | NIH-11179455 on NIH RePORTER |
What this research studies
If you receive care at one of the participating clinics, some clinics will use an enhanced CSC 2.0 model while others continue usual care, and outcomes will be compared across these sites. CSC 2.0 adds peer providers, digital outreach, family groups, coordination with emergency/inpatient providers and primary care, and cognitive remediation, all organized through a centrally managed hub-and-spoke system. The trial is cluster-randomized across a network of Massachusetts clinics affiliated with McLean Hospital and follows patients over time to see if these changes improve engagement and clinical outcomes. The approach was chosen based on clinic feedback about staffing and delivery challenges and aims to make proven early-intervention services work better in real-world settings.
Who could benefit from this research
Good fit: People who recently had a first episode of psychosis and are receiving care at one of the participating community clinics (in the Massachusetts network) are the best fit for this project.
Not a fit: People with long-standing psychotic disorders, those not treated at participating clinics, or those who cannot engage with the hub-and-spoke services are unlikely to benefit from this specific program.
Why it matters
Potential benefit: If successful, more people experiencing early psychosis could stay in care longer and have better symptoms, function, and recovery.
How similar studies have performed: Previous randomized trials and meta-analyses show coordinated specialty care improves outcomes after first-episode psychosis, but real-world clinics often struggle to deliver all components, so this work applies proven ideas to routine care.
Where this research is happening
Belmont, United States
- Mclean Hospital — Belmont, United States (Active)
Researchers
- Principal investigator: Ongur, Dost — Mclean Hospital
- Study coordinator: Ongur, Dost
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.