Engineering fibrous templates to reduce neutrophil activity in tissue regeneration.
Official title: Downregulation of neutrophil extracellular traps by fibrous regeneration template design.
Funded at University of Memphis · NIH-10654151 · Data updated 2026-11-12
This study is looking at new ways to create special materials that can help your body heal better by reducing harmful substances that can slow down recovery, and it aims to find out how these materials work through lab tests and experiments with rats, which could lead to better healing treatments for patients like you.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Memphis NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $414,779 |
| NIH project number | 1R15EB033752-01A1 |
| Project ID | NIH-10654151 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions requiring tissue regeneration, such as those recovering from surgery or injury.
✕Less likely to help
Patients with conditions unrelated to tissue regeneration or those not requiring surgical intervention may not benefit from this research.
What this research studies
This research investigates how to design fibrous templates that can reduce the secretion of neutrophil extracellular traps (NETs), which can hinder tissue integration during healing. By fabricating these templates with specific architectures and therapeutic compounds, the study aims to understand the mechanisms behind NETosis and how to control it. The research involves both in vitro experiments to test the templates and in vivo studies using a rat model to confirm the effectiveness of the designs in promoting better tissue integration. Patients may benefit from advancements in regenerative medicine that improve healing outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved healing processes and better integration of tissues in patients undergoing regenerative treatments.
How similar studies have gone: Previous research has shown promise in using engineered materials to influence immune responses, suggesting potential success for this novel approach.
Where this research is happening
-
University of Memphis
Memphis, United States Active
Researchers
- Principal investigator: Bowlin, Gary L — University of Memphis
- Study coordinator: Bowlin, Gary L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.