Engineering cells to improve their functions and characteristics
Official title: Combinatorial Cell State Engineering
Funded at Stanford University · NIH-10917076 · Data updated 2026-11-12
This study is exploring how changing certain genes in cells can help them behave differently, which could be really helpful for improving treatments in cell therapy and regenerative medicine.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,080,800 |
| NIH project number | 5DP1HG013599-02 |
| Project ID | NIH-10917076 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that could benefit from advanced cell therapies, such as genetic disorders or degenerative diseases.
✕Less likely to help
Patients who are not candidates for cell therapy or those with conditions that do not involve cellular dysfunction may not benefit from this research.
What this research studies
This research investigates how to manipulate multiple genes simultaneously to change the state and function of cells. By using advanced genetic screening techniques, the team aims to identify combinations of genes that can effectively alter cell behavior, particularly in the context of cell differentiation. The approach involves creating engineered libraries of genetic perturbations and applying machine learning to predict which combinations will yield the desired cellular outcomes. This could lead to significant advancements in cell therapy and regenerative medicine.
Why it matters
Potential benefit: If successful, this research could lead to more effective cell therapies that are tailored to treat various diseases.
How similar studies have gone: Other research has shown promising results using combinatorial genetic approaches to engineer cell states, indicating that this methodology has potential for success.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Greenleaf, William James — Stanford University
- Study coordinator: Greenleaf, William James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.