NIH-funded research U01 cooperative agreement

Engaging overdose survivors with SafeSpot to prevent repeat overdose

Official title: CE25-149 - Engaging Overdose Survivors with the SafeSpot Hotline for Secondary Overdose Prevention

Funded at Boston Medical Center · NIH-11422065 · Data updated 2026-11-12

A patient-facing program to help overdose survivors use a hotline and safety plan to reduce the chance of another overdose.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionBoston Medical Center
NIH-funded
Lab location1 site (Boston, United States)
Project startSeptember 30, 2025
Project endSeptember 29, 2030
Funding year2026
Award (this year)$699,573
NIH project number5U01CE003822-02
Project IDNIH-11422065 on NIH RePORTER

Who could benefit from this research

Could help

Adults who have survived an opioid overdose and are reachable to engage in safety planning and hotline use.

Less likely to help

Individuals without access to a phone or who are not willing to engage in safety planning may not benefit.

What this research studies

This project will develop and test a SafeSpot Overdose Safety Planning and Engagement (SOSPE) approach with survivors of opioid overdose. It involves practical steps like saving the SafeSpot number, practicing a call, and sending reminders to follow a safety plan. The study will partner with SafeSpot and a multidisciplinary team to tailor the intervention to survivors’ needs in real-world settings. If successful, it could provide a scalable way to support survivors and reduce repeat overdoses.

Why it matters

Potential benefit: If successful, survivors may have a clearer, more accessible way to get immediate help and reduce the risk of a repeat overdose.

How similar studies have gone: Previous hotline initiatives show promise but randomised testing of survivor-focused SOSPE-like approaches is limited.

Where this research is happening

  • Boston Medical Center
    Boston, United States
    Active

Researchers

  • Principal investigator: Walley, Alexander Yale — Boston Medical Center
  • Study coordinator: Walley, Alexander Yale

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.