Endothelial pathways in critical illness and organ injury
Official title: Endothelial mechanisms of multiorgan dysfunction
Funded at Albany Medical College · NIH-11392288 · Data updated 2026-11-12
A study exploring how lining of blood vessels drives organ failure in the sickest patients, with the goal of finding better ways to prevent long-term problems after critical illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 15, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $410,000 |
| NIH project number | 5R35GM152454-03 |
| Project ID | NIH-11392288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Anyone with severe critical illness in the ICU who experiences or is at risk for organ dysfunction and coagulation issues.
✕Less likely to help
Patients without severe inflammatory or vascular complications may have less direct benefit.
What this research studies
This project looks at how endothelial cells, which line blood vessels, respond to severe inflammation in critical care to cause organ damage and blood clotting problems. Researchers will study how signaling molecules affect vascular function and the development of post-intensive care syndrome, aiming to identify targets for new therapies. The work will integrate insights from blood coagulation, cardiovascular physiology, and cellular signaling to understand why some patients recover while others develop long-term impairments. The findings could point toward therapies that protect organs and reduce long-term disability after ICU stays.
Why it matters
Potential benefit: If successful, the project could lead to therapies that improve survival and reduce lasting disability after critical illness.
How similar studies have gone: Prior research supports a vascular mechanism in critical illness; this project builds on that foundation with a deeper endothelial focus.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Adam, Alejandro Pablo — Albany Medical College
- Study coordinator: Adam, Alejandro Pablo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.