ENCORE: improved ways to follow and prevent HIV in women across the United States

Enhanced Cohort methods for HIV Research and Epidemiology (ENCORE) in the United States

NIH-funded research Johns Hopkins University · NIH-11378939

This project uses a hub-supported digital approach to follow 3,000 women across the U.S. and track new HIV infections and related health conditions over time.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-11378939 on NIH RePORTER

What this research studies

If you join, local community hubs will help you sign up and stay connected while most participation happens through digital visits. You would be followed every six months for at least two years with surveys and health measurements to record HIV risk and other conditions like substance use or mental health concerns. The team will refine the digital methods to make enrollment and retention easier and use the data to model how social and structural factors affect HIV risk. The goal is to pinpoint better ways to target prevention and support services for women.

Who could benefit from this research

Good fit: Women living in the United States, especially those at higher risk for HIV or experiencing substance use, mental health, or structural vulnerabilities, are the intended participants.

Not a fit: Men, people living outside the United States, and those seeking immediate treatment or a cure rather than observational follow-up are unlikely to benefit directly from participating.

Why it matters

Potential benefit: If successful, this work could identify better prevention strategies and improve how women at risk for HIV are connected to care and services.

How similar studies have performed: Digital cohort approaches have been used in HIV research before, but the hub-supported hybrid model combining local community hubs with nationwide digital follow-up is relatively new.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.