Emerin’s role in muscle cell fate and muscle disease
Official title: Emerin regulation of myogenic differentiation: implications for muscle disease
Funded at Rowan University · NIH-11358900 · Data updated 2026-11-12
Aimed at understanding how the nuclear envelope protein emerin controls muscle cell development to help people with Emery-Dreifuss Muscular Dystrophy type 1.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rowan University NIH-funded |
| Lab location | 1 site (Glassboro, United States) |
| Project start | April 1, 2016 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $566,682 |
| NIH project number | 2R15AR069935-05 |
| Project ID | NIH-11358900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Emery-Dreifuss Muscular Dystrophy type 1 or related muscle-muscle regeneration issues.
✕Less likely to help
Healthy individuals or unrelated muscular conditions may not benefit directly.
What this research studies
This project looks at how emerin interacts with chromatin and enzymes to drive muscle stem cells to mature into healthy muscle. Researchers will map where emerin connects with HDAC3 and histone modifiers, and how these partnerships change during muscle differentiation. By using biochemical tests, imaging, and molecular techniques, they hope to reveal how disruptions in this network impair muscle formation and contribute to EDMD1. The findings could point to new ways to support muscle regeneration in affected patients.
Why it matters
Potential benefit: If successful, this work could guide new strategies to preserve or restore muscle function in EDMD1.
How similar studies have gone: Similar studies have linked chromatin regulation to muscle differentiation, with promising implications for neuromuscular diseases.
Where this research is happening
-
Rowan University
Glassboro, United States Active
Researchers
- Principal investigator: Holaska, James Michael — Rowan University
- Study coordinator: Holaska, James Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.