Embolization versus surgery for chronic subdural hematoma

Who could benefit from this research

What this research studies

You would be randomly assigned to receive either middle meningeal artery embolization, a minimally invasive procedure that blocks blood flow to the hematoma, or conventional surgery to remove the blood collection. The study is being run at multiple hospitals and is open-label, so you and your care team will know which treatment you get. Doctors will follow you for 180 days to see whether you need additional (rescue) surgery, experience complications, or die, and they will monitor for strokes, serious adverse events, seizures, and new or worsening neurological problems. The aim is to find out if embolization leads to fewer repeat operations and a safer recovery than standard surgery.

Why it matters

Where this research is happening

• University of Texas Med Br Galveston
  Galveston, United States Active

Researchers

• Principal investigator: Kan, Peter Tze Man — University of Texas Med Br Galveston
• Study coordinator: Kan, Peter Tze Man

Related research

Other NIH-funded projects on the same topics.

• NeoCast: A new embolic treatment for chronic subdural hematoma

  A new, fast-acting embolic therapy called NeoCast may reduce bleeding in chronic subdural hematoma patients and lower the need for extensive brain surgery.

  NIH research Arsenal Medical, INC. · Waltham, UNITED STATES · NIH-11409547

• Investigating brain stiffness to predict outcomes in chronic subdural hematoma treatment

  This study is looking at how the stiffness of the brain can help doctors understand and treat chronic subdural hematoma (a type of brain bleeding) in older adults, using special imaging to see how the brain responds after treatment.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11168998

• Comparing embolization and surgery for treating chronic subdural hematomas

  This study is looking at whether a new treatment called middle meningeal artery embolization (MMAE) is better than traditional surgery for helping people with chronic subdural hematomas, and it’s for patients who have moderate symptoms and want to see if this new option can lead to fewer surgeries and better recovery i

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11142185

• Middle Meningeal Artery Embolisation to Prevent Recurrence of Chronic Subdural Hematoma

  This study tests whether embolising the middle meningeal artery around the time of hematoma evacuation can reduce recurrence in adults with chronic subdural hematoma.

  Recruiting at 6 sites University Hospital Hradec Kralove · České Budějovice and 5 other locations · NCT07751887

• What causes vulnerability in older adults with serious diseases and how it affects care decisions

  This study tests how often vulnerability factors appear in older adults with serious illnesses and how these factors influence treatment timing, survival, and quality of life.

  Recruiting Tampere University Hospital · Tampere · NCT07740239

• Coil embolization for unilateral vs bilateral chronic subdural hematomas

  This trial tests whether unilateral or bilateral coil-based embolization of the middle meningeal artery helps people with chronic subdural hematoma.

  Recruiting Lahey Clinic · Burlington, Massachusetts · NCT07715656

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.