Eliminating HIV from immune cells
Targeting the HIV-1 Reservoir in Myeloid Cells
['FUNDING_R01'] · METHODIST HOSPITAL RESEARCH INSTITUTE · NIH-11113898
This study is exploring a new way to help people with HIV by finding and removing the cells in their bodies that hold the virus, using special treatments that make it easier to get rid of HIV for good.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | METHODIST HOSPITAL RESEARCH INSTITUTE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11113898 on ClinicalTrials.gov |
What this research studies
This research investigates a novel approach to eradicate HIV infections by selectively targeting and eliminating host cells that harbor the virus, particularly focusing on macrophages and microglia. The methodology involves enhancing the effectiveness of treatments that reactivate the virus, making it easier to clear from the body. By testing various drugs and agents in humanized mice, the research aims to improve the safety and efficacy of these treatments for HIV-infected patients. The ultimate goal is to find a way to clear the HIV reservoir in the immune system, which could lead to a functional cure for HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have not responded adequately to current treatments and have persistent viral reservoirs.
Not a fit: Patients who are not infected with HIV or those who have achieved viral suppression with current antiretroviral therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a breakthrough in the treatment of HIV, potentially allowing for the complete eradication of the virus from infected individuals.
How similar studies have performed: Previous research has shown promising results in similar approaches, particularly in animal models, but this specific method is still being tested for its efficacy in humans.
Where this research is happening
HOUSTON, UNITED STATES
- METHODIST HOSPITAL RESEARCH INSTITUTE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, JIN — METHODIST HOSPITAL RESEARCH INSTITUTE
- Study coordinator: WANG, JIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus