Effects of xylazine and fentanyl on breathing and body temperature in rats
Xylazine and fentanyl effects on rat breathing, metabolism, and thermoregulation
This study is looking at how a mix of two drugs, xylazine and fentanyl, affects breathing and body temperature in rats, which could help us understand the risks for people who might overdose on these substances.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10950412 on NIH RePORTER |
What this research studies
This research investigates how the combination of xylazine, a veterinary sedative, and fentanyl, a synthetic opioid, affects breathing, metabolism, and body temperature in rats. The study aims to understand the toxic effects of these drugs, both individually and together, particularly focusing on their impact on respiratory function and thermoregulation. By measuring various physiological responses, the researchers hope to uncover critical interactions that could inform medical management strategies for overdose victims. The findings may provide insights into how these substances contribute to severe health complications, including respiratory depression and impaired wound healing.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals who are at risk of overdose from opioids or sedatives, particularly those using xylazine and fentanyl.
Not a fit: Patients who do not use opioids or sedatives, or who are not at risk of overdose, may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for individuals affected by xylazine and fentanyl overdoses.
How similar studies have performed: While the specific combination of xylazine and fentanyl has not been extensively studied, research on the effects of opioids and sedatives has shown significant interactions and health risks.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Cotten, Joseph F — Massachusetts General Hospital
- Study coordinator: Cotten, Joseph F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.