Effects of traumatic brain injury on hypertensive rats
Official title: Neurobehavioral and pathophysiological effects of traumatic brain injury in spontaneously hypertensive rats
Funded at University of Pittsburgh at Pittsburgh · NIH-11075309 · Data updated 2026-11-12
This study looks at how a traumatic brain injury affects thinking and attention in rats with high blood pressure, helping us learn more about how these issues might impact people with similar conditions, so we can find better ways to help them recover.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $198,750 |
| NIH project number | 5R21NS137253-02 |
| Project ID | NIH-11075309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals who have experienced a traumatic brain injury and have a history of hypertension.
✕Less likely to help
Patients who have not experienced a traumatic brain injury or do not have hypertension may not receive direct benefits from this research.
What this research studies
This research investigates how traumatic brain injury (TBI) impacts neurological and cognitive functions in hypertensive rats, which serve as a model for understanding TBI in humans. The study focuses on the long-term effects of TBI, particularly in relation to attention impairments and other cognitive disabilities that may arise in individuals with hypertension. By using a series of behavioral assessments, the research aims to uncover the complex interactions between TBI and hypertension, ultimately enhancing our understanding of these conditions. The findings could lead to improved treatment strategies for individuals suffering from TBI, especially those with pre-existing hypertension.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with traumatic brain injuries, particularly those who also have hypertension.
How similar studies have gone: While there has been research on TBI and hypertension separately, this specific approach using hypertensive animal models to study TBI effects is relatively novel.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Bondi, Corina Oana — University of Pittsburgh at Pittsburgh
- Study coordinator: Bondi, Corina Oana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.