Effects of targeted cancer therapy on cognitive function in survivors
Official title: Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
Funded at H. Lee Moffitt Cancer Ctr & Res Inst · NIH-10999512 · Data updated 2026-11-12
This study is looking at how certain cancer treatments called tyrosine kinase inhibitors (TKIs) might affect thinking and memory in people who have survived chronic myeloid leukemia (CML) or chronic lymphocytic leukemia (CLL), so we can better understand the challenges they face while on these therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $700,049 |
| NIH project number | 1R01CA287666-01A1 |
| Project ID | NIH-10999512 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic myeloid leukemia or chronic lymphocytic leukemia who are about to begin treatment with tyrosine kinase inhibitors.
✕Less likely to help
Patients with cognitive impairments unrelated to cancer treatment or those not starting TKI therapy may not benefit from this research.
What this research studies
This research investigates how targeted therapies, specifically tyrosine kinase inhibitors (TKIs), affect cognitive function in cancer survivors, particularly those with chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). The study will assess both subjective and objective cognitive impairments using advanced neuropsychological tests and real-time assessments. By focusing on patients starting TKI treatment, the research aims to identify potential risk factors and mechanisms behind cognitive changes. This large-scale prospective study is designed to provide valuable insights into the cognitive challenges faced by cancer survivors undergoing targeted therapy.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for cognitive impairment in cancer survivors, enhancing their quality of life.
How similar studies have gone: Previous research has shown promising results in understanding cognitive impairment in cancer patients, but this specific focus on TKIs and their effects on cognitive function is relatively novel.
Where this research is happening
-
H. Lee Moffitt Cancer Ctr & Res Inst
Tampa, United States Active
Researchers
- Principal investigator: Gonzalez, Brian D — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Gonzalez, Brian D
Related research
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Impact of Targeted Cancer Therapy on Thinking and Memory
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How targeted cancer drugs affect thinking and memory
We will follow people with CML or CLL who are starting tyrosine kinase inhibitor treatment to find out if these targeted drugs change thinking, memory, or attention.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.