Effects of targeted cancer therapy on cognitive function in survivors
Impact of Targeted Therapy on Cancer-Related Cognitive Impairment
['FUNDING_R01'] · H. LEE MOFFITT CANCER CTR & RES INST · NIH-10999512
This study is looking at how certain cancer treatments called tyrosine kinase inhibitors (TKIs) might affect thinking and memory in people who have survived chronic myeloid leukemia (CML) or chronic lymphocytic leukemia (CLL), so we can better understand the challenges they face while on these therapies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | H. LEE MOFFITT CANCER CTR & RES INST (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-10999512 on ClinicalTrials.gov |
What this research studies
This research investigates how targeted therapies, specifically tyrosine kinase inhibitors (TKIs), affect cognitive function in cancer survivors, particularly those with chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL). The study will assess both subjective and objective cognitive impairments using advanced neuropsychological tests and real-time assessments. By focusing on patients starting TKI treatment, the research aims to identify potential risk factors and mechanisms behind cognitive changes. This large-scale prospective study is designed to provide valuable insights into the cognitive challenges faced by cancer survivors undergoing targeted therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic myeloid leukemia or chronic lymphocytic leukemia who are about to begin treatment with tyrosine kinase inhibitors.
Not a fit: Patients with cognitive impairments unrelated to cancer treatment or those not starting TKI therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for cognitive impairment in cancer survivors, enhancing their quality of life.
How similar studies have performed: Previous research has shown promising results in understanding cognitive impairment in cancer patients, but this specific focus on TKIs and their effects on cognitive function is relatively novel.
Where this research is happening
TAMPA, UNITED STATES
- H. LEE MOFFITT CANCER CTR & RES INST — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GONZALEZ, BRIAN D — H. LEE MOFFITT CANCER CTR & RES INST
- Study coordinator: GONZALEZ, BRIAN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.