Effects of T cell therapy on COVID-19 immunity after bone marrow transplant

Who could benefit from this research

What this research studies

This research investigates how adoptive T cell therapy can enhance the immune response to SARS-CoV-2 in children who have undergone bone marrow transplants. The study aims to assess the safety and effectiveness of using donor-derived T cells specifically targeting the virus to prevent infection in these vulnerable patients. By conducting a clinical trial, researchers will also explore ways to genetically modify these T cells to maintain their antiviral properties even when patients are treated with certain immunosuppressive medications. This approach could provide critical insights into improving post-transplant care for children.

Why it matters

Where this research is happening

• Children's Research Institute
  Washington, United States Active

Researchers

• Principal investigator: Conway, Susan — Children's Research Institute
• Study coordinator: Conway, Susan

Related research

Other NIH-funded projects on the same topics.

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• Boosting immunity to SARS-CoV-2 after bone marrow transplant using T cell therapy

  This project explores if special immune cells can help children and adults who have had a bone marrow transplant fight off SARS-CoV-2 infection.

  NIH research Children's Research Institute · Washington, United States · NIH-11162427

• Understanding how kidney transplant patients respond to COVID-19 vaccination while on specific immunosuppressive therapy

  This study is looking at how kidney transplant patients taking a medication called mycophenolate mofetil (MMF) respond to COVID-19 vaccines, and whether stopping this medication before getting vaccinated could help them build a stronger immune response and better protect them against the virus.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11046505

• How COVID-19 infection and genes may influence memory and dementia risk

  This study looks at how getting COVID-19 and a person’s genes together affect the chance of developing memory problems and Alzheimer’s disease later in life.

  NIH research University of Texas Hlth Science Center · San Antonio, United States · NIH-11617103

• Targeting early oral GVHD to improve mouth health after stem cell transplant

  A study at UW–Madison will explore why some transplant patients develop painful oral GVHD and test ideas to prevent and lessen mouth-related problems.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11616478

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.