Effects of T cell therapy on COVID-19 immunity after bone marrow transplant
K23 Resubmission - Impact of adoptive T cell therapy on immunity to SARS-CoV-2 after bone marrow transplant
This study is looking at how a special treatment using immune cells from donors can help protect children who have had bone marrow transplants from getting COVID-19, and it aims to find safe ways to make these cells even more effective while they are on medications that weaken their immune system.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Research Institute NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10886377 on NIH RePORTER |
What this research studies
This research investigates how adoptive T cell therapy can enhance the immune response to SARS-CoV-2 in children who have undergone bone marrow transplants. The study aims to assess the safety and effectiveness of using donor-derived T cells specifically targeting the virus to prevent infection in these vulnerable patients. By conducting a clinical trial, researchers will also explore ways to genetically modify these T cells to maintain their antiviral properties even when patients are treated with certain immunosuppressive medications. This approach could provide critical insights into improving post-transplant care for children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children who have recently undergone hematopoietic stem cell transplants and are at risk for SARS-CoV-2 infection.
Not a fit: Patients who are not post-bone marrow transplant or those who are not at risk for COVID-19 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the ability of children post-bone marrow transplant to fight off COVID-19 infections.
How similar studies have performed: Previous research has shown promise in using T cell therapies for viral infections, suggesting potential success for this novel approach.
Where this research is happening
Washington, United States
- Children's Research Institute — Washington, United States (Active)
Researchers
- Principal investigator: Conway, Susan — Children's Research Institute
- Study coordinator: Conway, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.