Effects of spinal cord stimulation on nerve changes in diabetic neuropathy patients
Functional and histological changes to peripheral innervation following spinal cord stimulation in patients with painful diabetic neuropathy
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10928275
This study is looking at how spinal cord stimulation can help relieve pain for people with painful diabetic nerve damage, and it will compare this treatment to regular medical care and a wait-and-see approach over 18 months.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10928275 on ClinicalTrials.gov |
What this research studies
This research investigates how spinal cord stimulation (SCS) can alleviate pain in patients suffering from painful diabetic peripheral neuropathy (PDPN). By applying electrical stimulation to the spinal nerves, the study aims to understand the underlying mechanisms that may promote nerve regeneration and improve pain management. Participants will be divided into three groups to compare the effectiveness of SCS against conventional medical management and a delayed activation of the device. The research will involve a comprehensive collection of data over 18 months to assess the functional and histological changes in peripheral innervation.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with painful diabetic peripheral neuropathy who have not found relief through conventional treatments.
Not a fit: Patients with neuropathy caused by conditions other than diabetes or those who have contraindications for spinal cord stimulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for patients with diabetic neuropathy, reducing reliance on opioid medications.
How similar studies have performed: Previous research has shown that spinal cord stimulation can effectively manage pain in various conditions, suggesting a promising avenue for treating diabetic neuropathy.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TOWNSEND, KRISTY L — OHIO STATE UNIVERSITY
- Study coordinator: TOWNSEND, KRISTY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus