Effects of spinal cord stimulation on nerve changes in diabetic neuropathy patients
Official title: Functional and histological changes to peripheral innervation following spinal cord stimulation in patients with painful diabetic neuropathy
Funded at Ohio State University · NIH-10928275 · Data updated 2026-11-12
This study is looking at how spinal cord stimulation can help relieve pain for people with painful diabetic nerve damage, and it will compare this treatment to regular medical care and a wait-and-see approach over 18 months.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 12, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $710,201 |
| NIH project number | 5R01DK138849-02 |
| Project ID | NIH-10928275 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with painful diabetic peripheral neuropathy who have not found relief through conventional treatments.
✕Less likely to help
Patients with neuropathy caused by conditions other than diabetes or those who have contraindications for spinal cord stimulation may not benefit from this research.
What this research studies
This research investigates how spinal cord stimulation (SCS) can alleviate pain in patients suffering from painful diabetic peripheral neuropathy (PDPN). By applying electrical stimulation to the spinal nerves, the study aims to understand the underlying mechanisms that may promote nerve regeneration and improve pain management. Participants will be divided into three groups to compare the effectiveness of SCS against conventional medical management and a delayed activation of the device. The research will involve a comprehensive collection of data over 18 months to assess the functional and histological changes in peripheral innervation.
Why it matters
Potential benefit: If successful, this research could lead to improved pain management strategies for patients with diabetic neuropathy, reducing reliance on opioid medications.
How similar studies have gone: Previous research has shown that spinal cord stimulation can effectively manage pain in various conditions, suggesting a promising avenue for treating diabetic neuropathy.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Townsend, Kristy L — Ohio State University
- Study coordinator: Townsend, Kristy L
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.