Effects of senolytics on vaccine responses in older adults
Impact of Senolytics on Aged Vaccine Responses
This study is looking at whether a special type of medicine can help older adults get better responses from their vaccines by removing certain aging cells that can weaken the immune system.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project ID | NIH-10975926 on NIH RePORTER |
What this research studies
This research investigates how senolytics, which are drugs that target and eliminate senescent cells, can improve vaccine responses in older adults. The study focuses on the immune system's response to vaccines, particularly in the context of aging, where immune responses are often weakened. By addressing the accumulation of senescent cells that contribute to inflammation and immune dysfunction, the research aims to enhance the effectiveness of vaccines for older individuals. Participants may receive senolytic treatment alongside vaccination to assess improvements in immune response.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who are receiving vaccinations, particularly for influenza.
Not a fit: Patients who are younger or do not have age-related immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines for older adults, reducing their risk of severe infections and improving overall health outcomes.
How similar studies have performed: Previous research has shown promise in using senolytics to improve health outcomes in aging populations, suggesting potential success for this approach.
Where this research is happening
Farmington, United States
- University of Connecticut Sch of Med/dnt — Farmington, United States (Active)
Researchers
- Principal investigator: Bartley, Jenna — University of Connecticut Sch of Med/dnt
- Study coordinator: Bartley, Jenna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.