Effects of prescription stimulants on drug overdoses

Impact of prescription stimulants on the drug overdose epidemic

NIH-funded research Mclean Hospital · NIH-11059981

This study is looking at how the rise in prescription stimulants, like amphetamines, might be linked to more drug overdoses during the COVID-19 pandemic, and it aims to find out if these medications can help people struggling with substance use issues stay sober and reduce overdose risks.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionMclean Hospital NIH-funded
Lab location1 site (Belmont, United States)
Project IDNIH-11059981 on NIH RePORTER

What this research studies

This research investigates the relationship between the increasing use of prescription stimulants, particularly amphetamines, and the rise in drug overdoses, especially during the COVID-19 pandemic. By analyzing real-world data, the study aims to understand whether the use of these stimulants contributes to the transition from prescription to illicit drug use, leading to fatal overdoses. The research will also explore if prescription stimulants can help individuals with substance use disorders achieve short-term abstinence and whether this has any impact on overdose rates.

Who could benefit from this research

Good fit: Ideal candidates for this research include adults over 21 who have a history of stimulant use or substance use disorders.

Not a fit: Patients who do not use prescription stimulants or have no history of substance use disorders may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide insights that help reduce the incidence of drug overdoses linked to stimulant use.

How similar studies have performed: While there is existing research on opioid use and its consequences, this specific investigation into prescription stimulants and their impact on overdoses is relatively novel.

Where this research is happening

Belmont, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.