Effects of postnatal Zika virus infection on brain development in infant macaques
Neurodevelopment after postnatal Zika virus infection in infant macaques
This study looks at how getting the Zika virus after birth affects the brain development of baby macaques, helping us understand the potential neurological problems and developmental challenges that can arise in young children during their crucial early years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10995332 on NIH RePORTER |
What this research studies
This research investigates the impact of Zika virus infection that occurs after birth on the brain development of infant macaques. It aims to understand how such infections can lead to neurological issues and developmental abnormalities, particularly in the first two years of life when the brain is rapidly maturing. The study will utilize a model of postnatal Zika virus infection in infant rhesus macaques to explore the neurobehavioral consequences at various stages of brain development, employing a range of methodologies from cellular analysis to whole-animal assessments.
Who could benefit from this research
Good fit: Ideal candidates for this research are infants who have been exposed to the Zika virus, particularly those born without microcephaly but at risk for postnatal neurological issues.
Not a fit: Patients who have not been exposed to the Zika virus or those who are older than two years may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide critical insights into the long-term effects of Zika virus on brain development, potentially informing treatment and prevention strategies for affected infants.
How similar studies have performed: Previous pilot studies have shown that postnatal Zika virus infection can lead to significant brain abnormalities, indicating that this research builds on promising preliminary findings.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Chahroudi, Ann M — Emory University
- Study coordinator: Chahroudi, Ann M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.