Effects of ovarian hormone suppression on brain structure and cognition in women
Impact of ovarian hormone suppression on regional and global brain architecture and cognition
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN DIEGO · NIH-10829903
This study is looking at how lowering certain hormones affects the brain and thinking skills in women with endometriosis, by comparing those on hormone treatment to those who aren't, to see how these changes might impact memory and attention.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN DIEGO (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10829903 on ClinicalTrials.gov |
What this research studies
This research investigates how the suppression of ovarian hormones affects brain structure and cognitive functions in women, particularly those with endometriosis. By comparing two groups of women aged 25 to 40, one receiving hormone suppression treatment and the other not, the study aims to understand the impact of hormonal changes on memory and attention. The research utilizes advanced imaging techniques to assess brain morphology and connectivity over several months, providing insights into the neuroprotective roles of hormones like estrogen and progesterone.
Who could benefit from this research
Good fit: Ideal candidates for this research are women aged 25 to 40 who have been diagnosed with endometriosis.
Not a fit: Patients outside the age range of 25 to 40 or those without a diagnosis of endometriosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of cognitive changes associated with hormonal fluctuations in women.
How similar studies have performed: Previous animal studies have shown promising results regarding the neuroprotective effects of ovarian hormones, suggesting that this human study could yield valuable insights.
Where this research is happening
LA JOLLA, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN DIEGO — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PANIZZON, MATTHEW S — UNIVERSITY OF CALIFORNIA, SAN DIEGO
- Study coordinator: PANIZZON, MATTHEW S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome