Effects of organophosphate exposure on brain structure and function
Official title: Inflammation and white matter microstructural alterations after OP exposure
Funded at Henry M. Jackson Fdn for the Adv Mil/med · NIH-10850386 · Data updated 2026-11-12
This study is looking at how being around certain chemicals called organophosphates might change the way our brain's white matter works over time, and it's for anyone interested in understanding the potential risks to brain health from these chemicals and finding ways to help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry M. Jackson Fdn for the Adv Mil/med NIH-funded |
| Lab location | 1 site (Bethesda, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $254,408 |
| NIH project number | 1R21NS136126-01 |
| Project ID | NIH-10850386 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been exposed to organophosphate compounds and are experiencing neurological symptoms.
✕Less likely to help
Patients who have not been exposed to organophosphate compounds or do not exhibit any neurological symptoms may not benefit from this research.
What this research studies
This research investigates how exposure to organophosphate compounds, which can occur in various civilian settings, affects the brain's white matter microstructure. It focuses on the long-term consequences of such exposure, particularly looking at how it alters brain connectivity and function. Using advanced imaging techniques, the study aims to identify the specific changes in brain structure that occur after exposure and to explore potential interventions to mitigate these effects. The research is particularly relevant for understanding the risks associated with organophosphate exposure and developing strategies to protect brain health.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals affected by organophosphate exposure.
How similar studies have gone: Previous research has shown that organophosphate exposure can lead to significant neurological effects, but this specific investigation into white matter microstructural alterations is relatively novel.
Where this research is happening
-
Henry M. Jackson Fdn for the Adv Mil/med
Bethesda, United States Active
Researchers
- Principal investigator: Marini, Ann M — Henry M. Jackson Fdn for the Adv Mil/med
- Study coordinator: Marini, Ann M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.