Effects of nicotine pouches on smokers looking to reduce smoking

Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers

['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-10934552

This study is looking at how nicotine pouches can help daily smokers who want to reduce their cigarette use, by comparing different strengths of pouches to a non-nicotine option over 16 weeks to see how it affects their health and cravings.

Quick facts

Phase['FUNDING_OTHER']
Study typeNih_funding
SexAll
SponsorPENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded)
Locations1 site (HERSHEY, UNITED STATES)
Trial IDNIH-10934552 on ClinicalTrials.gov

What this research studies

This research investigates the health effects of nicotine pouches among smokers who want to cut down on their cigarette use. It involves a randomized controlled trial where 330 daily smokers will be recruited and assigned to use nicotine pouches with varying nicotine levels or a placebo. Participants will be monitored over 16 weeks to assess changes in health indicators and addiction levels. The study aims to provide valuable information to the FDA regarding the safety and efficacy of nicotine pouches.

Who could benefit from this research

Good fit: Ideal candidates are current daily smokers who are interested in reducing their smoking but are not ready to quit entirely.

Not a fit: Patients who have never smoked or those who are not interested in reducing their smoking may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could help smokers reduce their cigarette consumption and improve their overall health.

How similar studies have performed: Other research has shown promising results in using nicotine replacement therapies to aid in smoking reduction, suggesting this approach may also be effective.

Where this research is happening

HERSHEY, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.

View on NIH RePORTER →

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.