Effects of nicotine pouches on smokers looking to reduce smoking
Official title: Project 3: Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10934552 · Data updated 2026-11-12
This study is looking at how nicotine pouches can help daily smokers who want to reduce their cigarette use, by comparing different strengths of pouches to a non-nicotine option over 16 weeks to see how it affects their health and cravings.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | September 30, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $1,050,903 |
| NIH project number | 5U54DA058271-02 |
| Project ID | NIH-10934552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are current daily smokers who are interested in reducing their smoking but are not ready to quit entirely.
✕Less likely to help
Patients who have never smoked or those who are not interested in reducing their smoking may not benefit from this research.
What this research studies
This research investigates the health effects of nicotine pouches among smokers who want to cut down on their cigarette use. It involves a randomized controlled trial where 330 daily smokers will be recruited and assigned to use nicotine pouches with varying nicotine levels or a placebo. Participants will be monitored over 16 weeks to assess changes in health indicators and addiction levels. The study aims to provide valuable information to the FDA regarding the safety and efficacy of nicotine pouches.
Why it matters
Potential benefit: If successful, this research could help smokers reduce their cigarette consumption and improve their overall health.
How similar studies have gone: Other research has shown promising results in using nicotine replacement therapies to aid in smoking reduction, suggesting this approach may also be effective.
Where this research is happening
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Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Foulds, Jonathan — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Foulds, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.