Effects of morphine and HIV proteins on brain function and behavior.
Official title: Impacts of morphine and HIV-Tat exposures and dimethylfumarate treatment on brain BDNF and mitochondrial and behavioral dysfunction.
Funded at University of Florida · NIH-11012305 · Data updated 2026-11-12
This study is looking at how morphine and HIV proteins influence brain health and behavior in people who have both opioid use disorder and HIV, with the hope of finding better ways to help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $665,637 |
| NIH project number | 5R01DA055568-03 |
| Project ID | NIH-11012305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who also struggle with opioid use disorder.
✕Less likely to help
Patients who do not have HIV or opioid use disorder may not benefit from this research.
What this research studies
This research investigates how morphine and HIV proteins affect brain function and behavior, particularly in individuals with opioid use disorder (OUD) and HIV. The study focuses on understanding the impact of these substances on mitochondrial function and brain-derived neurotrophic factor (BDNF) levels, which are crucial for brain health. By using animal models, the research aims to uncover the combined effects of these factors on behaviors that are relevant to human health outcomes. The findings could lead to improved treatment strategies for those suffering from both OUD and HIV.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals with opioid use disorder and HIV, potentially improving their mental and physical health.
How similar studies have gone: Other research has shown promising results in understanding the interactions between opioids and HIV, but this specific approach is relatively novel.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Mclaughlin, Jay P. — University of Florida
- Study coordinator: Mclaughlin, Jay P.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.