Effects of methamphetamine on brain cells and cognitive function
Methamphetamine Effects on Prefrontal Cortical PV+ Interneurons and Resulting Cognitive Deficits
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10886705
This study looks at how methamphetamine affects certain brain cells that help with thinking and memory, and it aims to understand how these changes might lead to problems like anxiety and addiction, so we can find better ways to help people who struggle with these issues.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10886705 on ClinicalTrials.gov |
What this research studies
This research investigates how methamphetamine affects specific brain cells known as parvalbumin positive fast spiking interneurons, which play a crucial role in cognitive functions like attention and memory. By studying both human and rodent models, the research aims to understand the changes in brain activity that lead to cognitive deficits associated with methamphetamine use. The approach includes examining the balance of excitatory and inhibitory signals in the brain, which may be disrupted by methamphetamine, leading to conditions such as anxiety, addiction, and autism spectrum disorders. The findings could provide insights into potential therapeutic targets for improving cognitive function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of methamphetamine use who are experiencing cognitive deficits or related neuropsychiatric disorders.
Not a fit: Patients who have not used methamphetamine or do not exhibit cognitive deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function in individuals affected by methamphetamine addiction and related disorders.
How similar studies have performed: Previous research has shown that similar approaches in studying the effects of drugs on brain function have yielded significant insights, suggesting that this research could build on established findings.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LAVIN, ANTONIETA — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: LAVIN, ANTONIETA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder