Effects of long-term skin inflammation on stem cells in the body
Official title: Long-term systemic consequences of type 2 skin inflammation on epithelial stem cells
Funded at Rockefeller University · NIH-11061751 · Data updated 2026-11-12
This study is looking at how long-lasting allergic skin reactions affect special skin cells that help heal and maintain your skin, focusing on a protein called TSLP that might change how these cells work after inflammation.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AR083275-02 |
| Project ID | NIH-11061751 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of allergic skin conditions such as atopic dermatitis or eczema.
✕Less likely to help
Patients with non-allergic skin conditions or those without a history of skin inflammation may not benefit from this research.
What this research studies
This research investigates how long-term allergic skin inflammation affects epithelial stem cells, which are crucial for repairing and maintaining skin and other barrier tissues. The study focuses on a specific protein called thymic stromal lymphopoietin (TSLP) that may influence the behavior and adaptability of these stem cells after experiencing inflammation. By examining the changes in stem cell function and their ability to heal wounds, the research aims to uncover important insights into the long-term consequences of allergic reactions on the body's healing processes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with allergic skin conditions and enhance our understanding of how these conditions affect overall health.
How similar studies have gone: Previous research has shown promising results in understanding the role of epithelial stem cells in response to inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Sajjath, Sairaj M — Rockefeller University
- Study coordinator: Sajjath, Sairaj M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.