Effects of long-term hormone therapy on brain function in prostate cancer patients
Official title: Neurocognitive Changes from Long-Term Androgen Deprivation Therapy in Prostate Cancer Patients
Funded at Yale University · NIH-10666534 · Data updated 2026-11-12
This study is looking at how long-term hormone therapy for prostate cancer might affect thinking and memory skills in patients, with the hope of finding ways to improve their quality of life and treatment choices.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | August 13, 2018 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $323,336 |
| NIH project number | 5R01CA218501-06 |
| Project ID | NIH-10666534 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are prostate cancer patients who are undergoing or have undergone androgen deprivation therapy.
✕Less likely to help
Patients who are not receiving androgen deprivation therapy or those with cognitive impairments unrelated to cancer treatment may not benefit from this research.
What this research studies
This research investigates how long-term androgen deprivation therapy (ADT) affects cognitive function in prostate cancer patients. By using neurocognitive tests, clinical assessments, and brain imaging techniques, the study aims to identify cognitive impairments and their impact on patients' quality of life. The goal is to understand the brain changes associated with ADT and to find biomarkers that could predict cognitive deficits, helping to improve treatment decisions for patients undergoing this therapy.
Why it matters
Potential benefit: If successful, this research could lead to better management of cognitive side effects in prostate cancer patients receiving hormone therapy.
How similar studies have gone: Previous research has indicated cognitive changes in patients undergoing similar hormone therapies, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Chao, Herta Huey-an — Yale University
- Study coordinator: Chao, Herta Huey-an
Related research
Other NIH-funded projects on the same topics.
-
Molecular tests to predict long-term response to hormone therapy and radiation for prostate cancer
This project looks for molecular signs in tumor samples that could show which men with prostate cancer returning after surgery will benefit most from hormone therapy plus radiation.
-
Identifying biomarkers to improve prostate cancer treatment outcomes after surgery.
This study is looking at how certain biological markers can help doctors figure out which men with prostate cancer, who have had surgery, will respond best to hormone therapy and radiation, so they can personalize treatments for better results.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.