Effects of long-term hormone therapy on brain function in prostate cancer patients
Neurocognitive Changes from Long-Term Androgen Deprivation Therapy in Prostate Cancer Patients
This study is looking at how long-term hormone therapy for prostate cancer might affect thinking and memory skills in patients, with the hope of finding ways to improve their quality of life and treatment choices.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10666534 on NIH RePORTER |
What this research studies
This research investigates how long-term androgen deprivation therapy (ADT) affects cognitive function in prostate cancer patients. By using neurocognitive tests, clinical assessments, and brain imaging techniques, the study aims to identify cognitive impairments and their impact on patients' quality of life. The goal is to understand the brain changes associated with ADT and to find biomarkers that could predict cognitive deficits, helping to improve treatment decisions for patients undergoing this therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are prostate cancer patients who are undergoing or have undergone androgen deprivation therapy.
Not a fit: Patients who are not receiving androgen deprivation therapy or those with cognitive impairments unrelated to cancer treatment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of cognitive side effects in prostate cancer patients receiving hormone therapy.
How similar studies have performed: Previous research has indicated cognitive changes in patients undergoing similar hormone therapies, suggesting that this area of investigation is both relevant and necessary.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Chao, Herta Huey-an — Yale University
- Study coordinator: Chao, Herta Huey-an
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.