Effects of light exposure on sleep and inflammation in multiple myeloma patients after stem cell transplantation
Official title: Systematic Light Exposure Effects on Circadian Rhythms Entrainment, Inflammation, Neutropenic Fever and Symptom Burden among Multiple Myeloma Patients undergoing Autologous Stem Cell Transplantation
Funded at Icahn School of Medicine at Mount Sinai · NIH-10876916 · Data updated 2026-11-12
This study is looking at whether getting morning light can help improve sleep, reduce inflammation, and lower the chances of fever in patients with multiple myeloma who are getting stem cell transplants, so they can feel better during their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 22, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $674,721 |
| NIH project number | 5R01CA260961-03 |
| Project ID | NIH-10876916 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with multiple myeloma who are scheduled to undergo autologous stem cell transplantation.
✕Less likely to help
Patients who are not undergoing autologous stem cell transplantation or those with other significant health conditions may not benefit from this research.
What this research studies
This research investigates how systematic exposure to light can help regulate circadian rhythms in patients with multiple myeloma who are undergoing autologous stem cell transplantation. The study aims to determine if morning light exposure can improve sleep quality, reduce inflammation, and lower the incidence of neutropenic fever, which are common issues faced by these patients. By measuring hormone levels and symptom burden, the research seeks to establish a link between light exposure and better health outcomes. Patients will be randomly assigned to receive either light therapy or standard care to assess the effectiveness of this approach.
Why it matters
Potential benefit: If successful, this research could lead to improved sleep, reduced inflammation, and better overall health outcomes for multiple myeloma patients undergoing treatment.
How similar studies have gone: Previous studies have shown promising results with light exposure improving sleep and reducing inflammation, indicating that this approach may be effective.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Valdimarsdottir, Heiddis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Valdimarsdottir, Heiddis
Related research
Other NIH-funded projects on the same topics.
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Morning light to improve sleep and reduce inflammation in multiple myeloma patients after stem cell transplant
A multi-site study will test whether exposure to circadian-friendly morning light helps multiple myeloma patients recover after autologous stem cell transplantation by improving sleep and reducing inflammation.
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Morning light to reset the body clock for multiple myeloma patients having autologous stem cell transplant
This project uses bright, circadian-friendly morning light in hospital rooms for people with multiple myeloma receiving autologous stem cell transplants to help them sleep better, lower inflammation, and reduce fevers and symptom burden.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
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Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
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How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
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Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.