Effects of iron overload and low oxygen on pregnancy in women with β-thalassemia
Official title: Pathological consequences of iron excess and hypoxia in β-thalassemia pregnancy
Funded at University of Florida · NIH-11049349 · Data updated 2026-11-12
This study looks at how too much iron and not enough oxygen during pregnancy can affect the health of women with β-thalassemia and their babies, aiming to find ways to make pregnancy safer for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 20, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $650,517 |
| NIH project number | 1R01DK137863-01A1 |
| Project ID | NIH-11049349 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant women diagnosed with β-thalassemia who are at risk of complications due to iron overload and anemia.
✕Less likely to help
Patients who do not have β-thalassemia or are not pregnant may not receive any benefit from this research.
What this research studies
This research investigates the impact of excess iron and low oxygen levels during pregnancy in women with β-thalassemia, a condition that can lead to serious health complications. Using a pre-clinical model, the study examines how these factors affect maternal health, placental function, and fetal development. The researchers aim to identify the molecular pathways involved in these adverse effects, which could help improve outcomes for both mothers and their babies. By understanding these mechanisms, the research seeks to address the high risks associated with pregnancy in β-thalassemia.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for pregnant women with β-thalassemia, improving health outcomes for both mothers and their infants.
How similar studies have gone: Previous research has shown that understanding the effects of iron overload and hypoxia can lead to significant advancements in managing related health conditions, suggesting that this approach has potential for success.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Collins, James F. — University of Florida
- Study coordinator: Collins, James F.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.