Effects of inhaling dihydroxyacetone from e-cigarettes on metabolism and cell function
Dihydroxyacetone exposure induces metabolic reprogramming and mitochondrial dysfunction
This study is looking at how breathing in a substance called dihydroxyacetone (DHA) from e-cigarette vapor affects the lungs and heart, especially how it might stress cells and change how they work, so we can better understand the effects of vaping on your health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10975961 on NIH RePORTER |
What this research studies
This research investigates how inhaling dihydroxyacetone (DHA), a compound found in e-cigarette vapor, affects metabolic processes and cell function in the lungs and cardiovascular system. The study aims to understand the cellular and metabolic stress caused by DHA exposure, focusing on both acute and chronic effects. Researchers will analyze how DHA alters metabolic pathways, induces oxidative stress, and disrupts calcium balance, potentially leading to mitochondrial dysfunction. By examining tissue samples from vapers, the research seeks to identify biomarkers that indicate the impact of repeated DHA inhalation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who regularly use e-cigarettes and are exposed to dihydroxyacetone through inhalation.
Not a fit: Patients who do not use e-cigarettes or are not exposed to dihydroxyacetone may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of the health risks associated with e-cigarette use and inform strategies to mitigate these risks.
How similar studies have performed: While there is existing research on the effects of DHA in skin models, this study is novel as it focuses on the inhalation exposure effects in pulmonary and cardiovascular cells.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Gassman, Natalie Rose — University of Alabama at Birmingham
- Study coordinator: Gassman, Natalie Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.