Effects of HPV integration on survival and spread in throat cancer
Official title: Downstream effects of HPV integration on survival/metastasis in oropharyngeal cancer
Funded at University of Michigan at Ann Arbor · NIH-10894220 · Data updated 2026-11-12
This study is looking at how the presence of HPV in throat cancer cells might influence how long patients live and whether their cancer spreads, with the goal of finding out if some patients can safely receive gentler treatments based on their HPV status.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2020 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $517,177 |
| NIH project number | 5R01CA250214-05 |
| Project ID | NIH-10894220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with HPV-positive oropharyngeal squamous cell carcinoma.
✕Less likely to help
Patients with HPV-negative oropharyngeal cancer or those with other types of head and neck cancers may not benefit from this research.
What this research studies
This research investigates how the integration of human papillomavirus (HPV) into the DNA of oropharyngeal cancer cells affects patient survival and the likelihood of cancer spreading to other parts of the body. The study aims to identify specific patient subgroups who may benefit from less aggressive treatment options based on their HPV integration status. By examining the biological mechanisms behind HPV integration, the research seeks to improve treatment strategies and outcomes for patients with HPV-related throat cancer.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment plans that improve survival rates and quality of life for patients with HPV-related oropharyngeal cancer.
How similar studies have gone: Previous research has shown promising results in understanding the role of HPV integration in cancer progression, indicating that this approach may yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Sartor, Maureen Agnes — University of Michigan at Ann Arbor
- Study coordinator: Sartor, Maureen Agnes
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.