Effects of hormone therapy on HIV in transgender women
Official title: Impact of Gender Affirming Hormone Therapy on HIV Viral Dynamics and Immune Responses in Transgender Women
Funded at Johns Hopkins University · NIH-11085774 · Data updated 2026-11-12
This study is looking at how hormone therapy affects the immune system and HIV levels in transgender women, aiming to better understand how these treatments can help manage HIV for those who are living with it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | November 18, 2024 |
| Project end | March 20, 2025 |
| Funding year | 2025 |
| Award (this year) | $771,490 |
| NIH project number | 1R01AI189309-01 |
| Project ID | NIH-11085774 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include transgender women, particularly those who are either living with HIV or are undergoing gender affirming hormone therapy.
✕Less likely to help
Patients who are not transgender women or those who do not have HIV may not benefit from this research.
What this research studies
This research investigates how gender affirming hormone therapy influences HIV viral dynamics and immune responses in transgender women. By examining two distinct cohorts, one with varying HIV serostatus and hormone exposure, and another from a clinical trial of transgender women living with HIV, the study aims to uncover specific immunological differences and the role of sex steroid hormones in HIV management. The goal is to fill a critical knowledge gap regarding the interaction between hormone therapy and HIV in this population.
Why it matters
Potential benefit: If successful, this research could lead to improved HIV treatment strategies tailored for transgender women.
How similar studies have gone: While there is existing data on HIV dynamics in cisgender populations, this specific approach focusing on transgender women and hormone therapy is relatively novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Scully, Eileen Patricia — Johns Hopkins University
- Study coordinator: Scully, Eileen Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.