Effects of HIV prevention medication on gut bacteria and inflammation
Changes in Enteric Microbiota and Inflammation with HIV PrEP
This study is looking at how starting PrEP for HIV might change the bacteria in your gut and affect inflammation, and it's for people who are beginning PrEP and want to understand its impact on their overall gut health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10913543 on NIH RePORTER |
What this research studies
This research investigates how Pre-Exposure Prophylaxis (PrEP) for HIV affects the gut microbiome and inflammation levels in patients. By enrolling participants who are starting PrEP and comparing them to a control group not using PrEP, the study will collect blood and stool samples to analyze changes in gut bacteria and viruses over three months. Advanced metagenomic sequencing techniques will be used to identify and characterize these microbial communities and their interactions, providing insights into how PrEP may influence gut health and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 0-11 years who are starting HIV PrEP or are part of a control group not using PrEP.
Not a fit: Patients who are not starting PrEP or are older than 11 years may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of the gut health implications of HIV prevention strategies, potentially informing better treatment protocols.
How similar studies have performed: While the specific approach of this research is novel, there have been other studies exploring the relationship between gut microbiota and HIV treatments, indicating potential for meaningful findings.
Where this research is happening
Seattle, United States
- Seattle Children's Hospital — Seattle, United States (Active)
Researchers
- Principal investigator: Maust, Brandon Swartz — Seattle Children's Hospital
- Study coordinator: Maust, Brandon Swartz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.