Effects of HIV prevention medication on gut bacteria and inflammation
Official title: Changes in Enteric Microbiota and Inflammation with HIV PrEP
Funded at Seattle Children's Hospital · NIH-10913543 · Data updated 2026-11-12
This study is looking at how starting PrEP for HIV might change the bacteria in your gut and affect inflammation, and it's for people who are beginning PrEP and want to understand its impact on their overall gut health.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $193,540 |
| NIH project number | 5K08AI177080-02 |
| Project ID | NIH-10913543 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 0-11 years who are starting HIV PrEP or are part of a control group not using PrEP.
✕Less likely to help
Patients who are not starting PrEP or are older than 11 years may not receive benefit from this research.
What this research studies
This research investigates how Pre-Exposure Prophylaxis (PrEP) for HIV affects the gut microbiome and inflammation levels in patients. By enrolling participants who are starting PrEP and comparing them to a control group not using PrEP, the study will collect blood and stool samples to analyze changes in gut bacteria and viruses over three months. Advanced metagenomic sequencing techniques will be used to identify and characterize these microbial communities and their interactions, providing insights into how PrEP may influence gut health and inflammation.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of the gut health implications of HIV prevention strategies, potentially informing better treatment protocols.
How similar studies have gone: While the specific approach of this research is novel, there have been other studies exploring the relationship between gut microbiota and HIV treatments, indicating potential for meaningful findings.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Maust, Brandon Swartz — Seattle Children's Hospital
- Study coordinator: Maust, Brandon Swartz
Related research
Other NIH-funded projects on the same topics.
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Understanding how HIV PrEP affects gut microbes and inflammation
A doctor-scientist team will study how HIV prevention pills may change gut viruses and bacteria and whether that relates to gut inflammation in people starting PrEP.
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mChoice: Boosting PrEP Use and Adherence for Black and Latino MSM with Tailored Training and Support
A national study to help Black and Latino men who have sex with men start and stick with PrEP through culturally matched provider training and patient support.
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Harnessing male peer networks to boost HIV testing and PrEP use
A large clinical trial in South Africa tests whether giving HIV self-test kits through male peer networks, with phone support, increases PrEP uptake among men.
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Harnessing men's peer networks to boost HIV self-testing and PrEP use
A large project in South Africa tests whether giving HIV self-test kits through men’s social networks, with phone support, can lead to more men starting PrEP and using HIV testing.
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Diet, gut microbiome, and immune health in adults with type 2 diabetes
A study at Stanford is exploring how fermented foods and their molecules, like lactate, influence gut bacteria and the body's immune and inflammatory responses in adults with adult-onset diabetes.
-
Participatory system dynamics to improve PrEP access in the Bronx
A community-driven project in the Bronx will use system dynamics to identify practical ways to help people at risk for HIV start and stay on PrEP.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.