Effects of HIV and antiretroviral therapy on bone health
Impact of HIV and antiretroviral initiation on skeletal biology
This study is looking at how HIV and certain treatments for it affect bone health, and it's for adults who have just been diagnosed with HIV and are starting a new medication that might be easier on their bones; you'll get some tests to check your bone strength and health over time.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10657701 on NIH RePORTER |
What this research studies
This research investigates how HIV and different antiretroviral therapies (ART) impact bone health, particularly focusing on bone mineral density and strength. The study aims to enroll adult individuals who are newly diagnosed with HIV and are starting a specific ART regimen that is believed to have less negative impact on bones. Participants will undergo various assessments, including bone density scans and biopsies, to understand the changes in their skeletal biology over time. The research is a collaboration between Columbia University and the University of São Paulo, utilizing advanced imaging and analysis techniques to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are adult men and women who are ART-naïve and are beginning treatment for HIV.
Not a fit: Patients who are already on antiretroviral therapy or those with pre-existing severe bone conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that minimize bone loss in individuals living with HIV.
How similar studies have performed: Previous studies have shown that certain ART regimens can significantly affect bone health, indicating that this research could build on established findings.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Yin, Michael T — Columbia University Health Sciences
- Study coordinator: Yin, Michael T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.