Effects of high levels of a hormone called FGF23 on heart health in kidney disease.
Consequences of Elevated Fibroblast Growth Factor 23 in the Presence and Absence of Kidney Disease
This study is looking at how high levels of a hormone called FGF23 might affect heart health in people with chronic kidney disease and those on dialysis, using a special mouse model to help find ways to improve treatment for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10415972 on NIH RePORTER |
What this research studies
This research investigates how elevated levels of fibroblast growth factor 23 (FGF23) impact cardiovascular health in patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD). The study utilizes a specialized mouse model to explore the relationship between FGF23 and cardiovascular complications, aiming to clarify the hormone's role in heart disease associated with kidney dysfunction. By understanding these mechanisms, the research seeks to identify potential therapeutic targets to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic kidney disease or end-stage renal disease.
Not a fit: Patients without kidney disease or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce cardiovascular risks for patients with kidney disease.
How similar studies have performed: Previous studies have shown associations between FGF23 and cardiovascular outcomes, but this research aims to provide novel insights into its direct effects, making it a potentially groundbreaking investigation.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Gattineni, Jyothsna — Ut Southwestern Medical Center
- Study coordinator: Gattineni, Jyothsna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.