Effects of high frequency head impacts on brain function and behavior
Tau-independent effects of high frequency head impact on cognition and neurobehavior
This study looks at how getting hit in the head often, like in contact sports, can impact thinking and behavior, especially related to Alzheimer's and aggression, and it aims to uncover the reasons behind these changes using animal models.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-10447059 on NIH RePORTER |
What this research studies
This research investigates how repeated head impacts, common in contact sports, affect cognitive abilities and behavior, particularly in relation to conditions like Alzheimer's disease and aggressive behavior. It aims to understand the mechanisms behind these effects, focusing on factors beyond the well-known tau protein accumulation. By using animal models, the study explores the relationship between traumatic brain injuries and long-term cognitive and behavioral changes, providing insights into the underlying causes of these issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of repeated head impacts, such as athletes in contact sports, who may experience cognitive or behavioral changes.
Not a fit: Patients who have not experienced head impacts or do not exhibit cognitive or behavioral symptoms related to such impacts may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for cognitive impairments and behavioral issues associated with head injuries.
How similar studies have performed: Previous research has shown partial success in understanding cognitive deficits related to head impacts, but this specific approach exploring tau-independent mechanisms is relatively novel.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Burns, Mark P — Georgetown University
- Study coordinator: Burns, Mark P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.