Effects of genetics and metabolism on bone health in Mexican Americans with diabetes
Official title: Genomic, transcriptomic, and metabolic effects on skeletal health in Mexican Americans
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11018617 · Data updated 2026-11-12
This study is looking at how genetics and other factors affect bone health in Mexican Americans with type 2 diabetes, to find out why they might have a higher risk of fractures even when their bone density seems normal, and it involves tests like genetic screening and imaging to learn more about their bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $649,676 |
| NIH project number | 5R01AG078452-03 |
| Project ID | NIH-11018617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are Mexican Americans aged 21 and older who have been diagnosed with type 2 diabetes.
✕Less likely to help
Patients who do not have type 2 diabetes or are not of Mexican American descent may not benefit from this research.
What this research studies
This research investigates how genetic, metabolic, and transcriptomic factors influence bone health in Mexican Americans with type 2 diabetes. It aims to identify the underlying reasons for increased fracture risk in this population, despite normal bone mineral density readings. By examining bone turnover rates and other indirect measures of bone quality, the study seeks to uncover critical insights into skeletal health. Participants will undergo assessments that include genetic testing and imaging to better understand their bone health.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and treatment strategies for bone health in Mexican Americans with type 2 diabetes.
How similar studies have gone: Previous research has shown success in identifying bone health issues in other populations, but this specific focus on Mexican Americans with diabetes is relatively novel.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Lee, Miryoung — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Lee, Miryoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.