Effects of genetics and metabolism on bone health in Mexican Americans with diabetes
Genomic, transcriptomic, and metabolic effects on skeletal health in Mexican Americans
This study is looking at how genetics and other factors affect bone health in Mexican Americans with type 2 diabetes, to find out why they might have a higher risk of fractures even when their bone density seems normal, and it involves tests like genetic screening and imaging to learn more about their bones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11018617 on NIH RePORTER |
What this research studies
This research investigates how genetic, metabolic, and transcriptomic factors influence bone health in Mexican Americans with type 2 diabetes. It aims to identify the underlying reasons for increased fracture risk in this population, despite normal bone mineral density readings. By examining bone turnover rates and other indirect measures of bone quality, the study seeks to uncover critical insights into skeletal health. Participants will undergo assessments that include genetic testing and imaging to better understand their bone health.
Who could benefit from this research
Good fit: Ideal candidates are Mexican Americans aged 21 and older who have been diagnosed with type 2 diabetes.
Not a fit: Patients who do not have type 2 diabetes or are not of Mexican American descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved screening and treatment strategies for bone health in Mexican Americans with type 2 diabetes.
How similar studies have performed: Previous research has shown success in identifying bone health issues in other populations, but this specific focus on Mexican Americans with diabetes is relatively novel.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Lee, Miryoung — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Lee, Miryoung
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.