Effects of fluoxetine on HIV treatment with dolutegravir in patients with depression
Official title: Influence of fluoxetine on the disposition kinetics of dolutegravir among people living with HIV with major depression in Nigeria
Funded at College of Medicine, University of Ibadan · NIH-10878931 · Data updated 2026-11-12
This study is looking at how the antidepressant fluoxetine affects the HIV medication dolutegravir in people living with HIV and major depression, especially in Nigeria, to help find better ways to manage both conditions together.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Medicine, University of Ibadan NIH-funded |
| Lab location | 1 site (Ibadan, Nigeria) |
| Project start | August 2, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $71,729 |
| NIH project number | 5K43TW011995-03 |
| Project ID | NIH-10878931 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults living with HIV who are also diagnosed with major depression.
✕Less likely to help
Patients who do not have HIV or major depression may not benefit from this research.
What this research studies
This research investigates how the antidepressant fluoxetine affects the levels of the HIV medication dolutegravir in people living with HIV who also have major depression. The study will involve pharmacokinetic assessments to understand the interaction between these two medications, which may impact treatment adherence and overall health outcomes. By focusing on patients in Nigeria, the research aims to address the unique challenges faced by individuals in low to medium-income countries. The findings could lead to improved treatment strategies for managing both HIV and depression.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of HIV treatment regimens for patients dealing with depression, leading to better health outcomes.
How similar studies have gone: Previous research has shown that drug interactions can significantly affect treatment outcomes in HIV patients, suggesting that this approach could yield valuable insights.
Where this research is happening
-
College of Medicine, University of Ibadan
Ibadan, Nigeria Active
Researchers
- Principal investigator: Adedeji, Waheed Adeola — College of Medicine, University of Ibadan
- Study coordinator: Adedeji, Waheed Adeola
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.