Effects of flavored e-cigarette aerosols on lung cells
Alveolar epithelial cell dysfunction induced by flavored e-cigarette aerosols
This study is looking at how flavored e-cigarette smoke affects important lung cells that help keep your lungs healthy, especially focusing on whether fruity and dessert flavors can harm these cells, and it will also check if a special protein can help protect them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10909923 on NIH RePORTER |
What this research studies
This research investigates how flavored e-cigarette aerosols impact alveolar type II (ATII) cells, which are crucial for lung function and repair. The study focuses on the potential mitochondrial damage caused by these aerosols, particularly from fruit and dessert flavors. By examining human and mouse lung cells, the researchers aim to understand the mechanisms behind cell death and dysfunction induced by e-cigarette use. The project will also explore the protective role of a protein called DJ-1 in these processes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who use flavored e-cigarettes and may be experiencing respiratory issues.
Not a fit: Patients who do not use e-cigarettes or flavored products may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of lung damage associated with flavored e-cigarette use.
How similar studies have performed: While the specific focus on flavored e-cigarette aerosols is relatively novel, previous research has shown harmful effects of e-cigarette use on lung health.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kosmider, Beata — Temple Univ of the Commonwealth
- Study coordinator: Kosmider, Beata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.