Effects of flame retardants on thyroid hormone regulation during pregnancy
Flame retardant effects on thyroid hormone regulation at the fetal-maternal interface of the placenta
['FUNDING_U01'] · DUKE UNIVERSITY · NIH-10813006
This study looks at how certain chemicals called flame retardants might affect thyroid hormones during pregnancy and how this could influence the growth and development of babies, especially comparing boys and girls, using both human and rat samples to better understand any potential risks to newborns.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10813006 on ClinicalTrials.gov |
What this research studies
This research investigates how exposure to flame retardants affects thyroid hormone regulation at the fetal-maternal interface of the placenta. It aims to understand the impact of these chemicals on fetal growth and development, particularly focusing on differences between male and female infants. The study utilizes both human placental tissues and a rat model to explore how these substances accumulate in the placenta and their potential effects on birth outcomes. By examining the mechanisms involved, the research seeks to identify environmental factors that may contribute to adverse birth outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals exposed to flame retardants or those concerned about environmental factors affecting fetal health.
Not a fit: Patients who are not pregnant or those without exposure to flame retardants may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and prevention of low birth weight and other adverse health outcomes in infants.
How similar studies have performed: Previous research has indicated that environmental exposures, including flame retardants, can significantly impact fetal development, suggesting that this approach is grounded in established findings.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: STAPLETON, HEATHER M — DUKE UNIVERSITY
- Study coordinator: STAPLETON, HEATHER M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiovascular Diseases, cardiovascular disorder