Effects of exercise training on muscle metabolism and health
Official title: Investigating the effects of aerobic and resistance training in vivo on skeletal muscle metabolism in vitro in primary human muscle cells (MoTrMyo)
Funded at Adventhealth Orlando · NIH-10839757 · Data updated 2026-11-12
This study is looking at how different kinds of exercise, like running or lifting weights, can help your muscle cells work better and stay healthy, which could be really helpful for anyone wanting to improve their metabolism and reduce the risk of health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Adventhealth Orlando NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project start | August 1, 2019 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $596,250 |
| NIH project number | 5R01DK120322-05 |
| Project ID | NIH-10839757 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are physically active or those looking to improve their exercise capacity and metabolic health.
✕Less likely to help
Patients who are unable to engage in any form of exercise or have severe mobility limitations may not benefit from this research.
What this research studies
This research investigates how different types of exercise, specifically aerobic and resistance training, affect the metabolism of skeletal muscle cells. By examining primary human muscle cells, the study aims to understand how these exercises can influence muscle function and overall health. The research will look at how short-term and lifelong exercise regimens can lead to changes at the cellular level, potentially improving insulin sensitivity and reducing the risk of metabolic diseases. Patients may benefit from insights into how exercise can be tailored to enhance muscle health and metabolic function.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise recommendations that enhance muscle health and reduce the risk of metabolic diseases for patients.
How similar studies have gone: Previous research has shown promising results in understanding the impact of exercise on muscle metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Adventhealth Orlando
Orlando, United States Active
Researchers
- Principal investigator: Sparks, Lauren Marie — Adventhealth Orlando
- Study coordinator: Sparks, Lauren Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.