Effects of exercise training on heart failure with preserved ejection fraction
Official title: Efficacy of exercise training in patients with HFpEF
Funded at VA Salt Lake City Healthcare System · NIH-10938020 · Data updated 2026-11-12
This study is looking at how exercise can help people with heart failure feel better and be more active by understanding how certain nerves affect blood flow and tiredness during workouts, so we can create better exercise plans just for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Salt Lake City Healthcare System NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | October 1, 2020 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01RX003343-05 |
| Project ID | NIH-10938020 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with heart failure with preserved ejection fraction who experience exercise intolerance.
✕Less likely to help
Patients with heart failure with reduced ejection fraction or those without heart failure may not benefit from this research.
What this research studies
This research investigates how exercise training can improve the ability of patients with heart failure with preserved ejection fraction (HFpEF) to engage in physical activity. It focuses on understanding the role of specific muscle afferents in regulating blood flow and fatigue during exercise. By using advanced techniques, including nerve blocks and magnetic resonance spectroscopy, the study aims to identify how these factors contribute to exercise intolerance in HFpEF patients. The findings could help develop targeted exercise programs to enhance physical function and quality of life.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise tolerance and overall quality of life for patients with HFpEF.
How similar studies have gone: Previous research has shown that exercise training can be beneficial for heart failure patients, but this specific approach focusing on muscle afferents is relatively novel.
Where this research is happening
-
VA Salt Lake City Healthcare System
Salt Lake City, United States Active
Researchers
- Principal investigator: Amann, Markus — VA Salt Lake City Healthcare System
- Study coordinator: Amann, Markus
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.