Effects of exercise on respiratory issues caused by a cancer drug
Doxorubicin-induced respiratory dysfunction and the protective effects of exercise
This study is looking at how the cancer drug doxorubicin might cause breathing issues and problems with the diaphragm muscle, and it wants to see if doing endurance exercise before treatment can help protect against these side effects, making life a little easier for patients during their cancer journey.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10641895 on NIH RePORTER |
What this research studies
This research investigates how the cancer drug doxorubicin can lead to respiratory problems and diaphragm muscle dysfunction in patients. It aims to understand the mechanisms behind these side effects and explore whether endurance exercise training before treatment can reduce the harmful accumulation of the drug in the diaphragm. By focusing on mitochondrial health, the study seeks to find ways to protect patients from the debilitating effects of doxorubicin, potentially improving their quality of life during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are cancer patients who are prescribed doxorubicin and may experience respiratory dysfunction.
Not a fit: Patients who are not receiving doxorubicin or those with pre-existing severe respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could help reduce respiratory complications in cancer patients undergoing treatment with doxorubicin.
How similar studies have performed: Previous research has shown that exercise can mitigate some side effects of cancer treatments, suggesting potential success for this approach.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Smuder, Ashley — University of Florida
- Study coordinator: Smuder, Ashley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.