Effects of excess testosterone during pregnancy on future generations
Multigenerational Effects of Gestational Testosterone Excess
This study looks at how high levels of testosterone during pregnancy might impact the reproductive and metabolic health of offspring, especially in females, and aims to find ways to improve fertility and prevent issues like polycystic ovary syndrome (PCOS) for future generations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10849640 on NIH RePORTER |
What this research studies
This research investigates how exposure to high levels of testosterone during pregnancy can affect the reproductive and metabolic health of offspring. By studying sheep as a model, the researchers aim to understand the mechanisms that lead to reproductive issues such as infertility and conditions like polycystic ovary syndrome (PCOS) in females. The study explores how these effects may be passed down to subsequent generations and seeks to develop strategies to improve reproductive health. Patients may benefit from insights that could lead to better prevention and treatment options for fertility-related disorders.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include women experiencing infertility or reproductive health issues, particularly those with a family history of conditions like PCOS.
Not a fit: Patients who are not experiencing reproductive health issues or infertility may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of infertility and reproductive health issues in women.
How similar studies have performed: Other research has shown success in understanding the effects of prenatal hormone exposure on reproductive health, indicating that this approach has potential for significant findings.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Padmanabhan, Vasantha — University of Michigan at Ann Arbor
- Study coordinator: Padmanabhan, Vasantha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.