Effects of estrogen therapy on bone health in older women with HIV
Official title: Impact of estrogen replacement therapy on bone health in an aging population of women living with HIV
Funded at Oregon Health & Science University · NIH-11008165 · Data updated 2026-11-12
This study is looking at whether estrogen replacement therapy can help improve bone health in older women with HIV who are going through menopause, especially since both menopause and HIV treatment can affect bone strength.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | August 6, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $205,603 |
| NIH project number | 1K01AI183927-01A1 |
| Project ID | NIH-11008165 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are postmenopausal women living with HIV who are undergoing or have undergone antiretroviral therapy.
✕Less likely to help
Patients who are not postmenopausal or those who do not have HIV may not benefit from this research.
What this research studies
This research investigates how estrogen replacement therapy can improve bone health in aging women living with HIV, particularly as they experience menopause. It focuses on the combined effects of antiretroviral therapy (ART) and menopause on bone density and fracture risk. Using a unique non-human primate model, the study will assess changes in bone architecture and quality, as well as the presence of bone cell precursors in the bone marrow. The goal is to determine if estrogen therapy can mitigate bone loss associated with both aging and HIV treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved bone health and reduced fracture risk for aging women living with HIV.
How similar studies have gone: Previous research has shown promising results in hormone replacement therapies for bone health, suggesting potential success for this approach in the context of HIV.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Sauter, Kristin Ad — Oregon Health & Science University
- Study coordinator: Sauter, Kristin Ad
Related research
Other NIH-funded projects on the same topics.
-
Aging Well with HIV: Alcohol, Risk Reduction, and Education Center (AWAR3E)
A center at Yale is exploring how aging with HIV interacts with alcohol use to create inflammation and frailty, with the goal of finding biomarkers and potential treatments.
-
Cognitive SuperAging: Exploring why some octogenarians stay sharp in memory
This NIH grant studies why a small group of people aged 80+ keep memory skills as good as much younger people, hoping to understand how to protect memory as we age.
-
Biological aging across the lifespan through a national high school-to-adult study
This grant uses a long-running national study of students and adults to collect saliva biomarkers of aging, alongside surveys, to understand how aging markers relate to health and life experiences.
-
Understanding how aging and Alzheimer’s affect how people make tough choices
This NIH grant studies how aging and Alzheimer’s risk change how people decide between immediate and delayed rewards and risky options, with the goal of helping older adults stay financially and healthwise safer.
-
Understanding how brain resilience and multiple brain pathologies influence aging and Alzheimer's disease
A long-term study follows older adults to learn how resilience to brain changes helps reduce dementia risk and what biological factors are linked to better cognitive aging.
-
National Neighborhood Data Archive helps researchers study aging health in U.S. neighborhoods
A nationwide data resource will help researchers understand how where people live affects health and aging, with a focus on respiratory illnesses in older adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.