Effects of estrogen therapy on bone health in older women with HIV
Impact of estrogen replacement therapy on bone health in an aging population of women living with HIV
This study is looking at whether estrogen replacement therapy can help improve bone health in older women with HIV who are going through menopause, especially since both menopause and HIV treatment can affect bone strength.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-11008165 on NIH RePORTER |
What this research studies
This research investigates how estrogen replacement therapy can improve bone health in aging women living with HIV, particularly as they experience menopause. It focuses on the combined effects of antiretroviral therapy (ART) and menopause on bone density and fracture risk. Using a unique non-human primate model, the study will assess changes in bone architecture and quality, as well as the presence of bone cell precursors in the bone marrow. The goal is to determine if estrogen therapy can mitigate bone loss associated with both aging and HIV treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women living with HIV who are undergoing or have undergone antiretroviral therapy.
Not a fit: Patients who are not postmenopausal or those who do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved bone health and reduced fracture risk for aging women living with HIV.
How similar studies have performed: Previous research has shown promising results in hormone replacement therapies for bone health, suggesting potential success for this approach in the context of HIV.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Sauter, Kristin Ad — Oregon Health & Science University
- Study coordinator: Sauter, Kristin Ad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.