Effects of drug abuse on HIV in the brain
Impact of drugs of abuse on HIV brain reservoirs and HAND in humanized microglia mice
This study looks at how drug use affects the way HIV hides in the brain, which can change how the disease progresses, and it's designed for people living with HIV who want to understand more about how their condition might be influenced by substance use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-11082362 on NIH RePORTER |
What this research studies
This research investigates how drug abuse influences the establishment and size of HIV reservoirs in the brain, which can affect disease progression and severity. Using a specialized mouse model that mimics human immune and brain cells, the study aims to understand the dynamics of HIV infection in the central nervous system. By examining how substance use impacts these reservoirs, the research seeks to identify potential interventions for better management of HIV-related neurocognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of drug abuse.
Not a fit: Patients who are HIV-negative or do not have a history of substance abuse may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing HIV infection and its neurological complications in patients with a history of substance abuse.
How similar studies have performed: Previous research has shown that understanding the interactions between drug abuse and HIV can lead to significant advancements in treatment approaches, indicating that this area of study is both relevant and promising.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Gorantla, Santhi — University of Nebraska Medical Center
- Study coordinator: Gorantla, Santhi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.